BACE : Lead Target for Orchestrated Therapy of Alzheimer's Disease /
BACE inhibitors and their use in the treatment of Alzheimer's Disease. BACE (ß-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated The...
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Hoboken, N.J. :
John Wiley & Sons,
©2010.
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| Subjects: | |
| Online Access: |
Full text (Emmanuel users only) |
MARC
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| 245 | 0 | 0 | |a BACE : |b Lead Target for Orchestrated Therapy of Alzheimer's Disease / |c edited by Varghese John. |
| 246 | 3 | 0 | |a Beta-site APP Cleaving Enzyme |
| 260 | |a Hoboken, N.J. : |b John Wiley & Sons, |c ©2010. | ||
| 300 | |a 1 online resource (1 electronic resource (xvi, 250 pages, 16 unnumbered pages of plates)) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a data file |2 rda | ||
| 380 | |a Bibliography | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon [and others]. | |
| 506 | |a Access restricted to Ryerson students, faculty and staff. |5 CaOTR | ||
| 520 | |a BACE inhibitors and their use in the treatment of Alzheimer's Disease. BACE (ß-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and. | ||
| 546 | |a English. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Alzheimer's disease |x Chemotherapy. | |
| 650 | 0 | |a Aspartic proteinases |x Inhibitors |x Therapeutic use. | |
| 650 | 0 | |a Amyloid beta-protein precursor. | |
| 650 | 1 | 2 | |a Alzheimer Disease |x drug therapy |
| 650 | 2 | 2 | |a Amyloid Precursor Protein Secretases |x pharmacology |
| 650 | 2 | 2 | |a Amyloid Precursor Protein Secretases |x therapeutic use |
| 650 | 2 | |a Amyloid beta-Protein Precursor | |
| 700 | 1 | |a John, Varghese, |d 1958- |1 https://id.oclc.org/worldcat/entity/E39PCjCWckmyTW4VbT7C9hD8YP | |
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