Copper-mediated cross-coupling reactions /
"Providing insight into the use of copper in cross-coupling reactions as a cost-efficient alternative to palladium, Copper-Mediated Cross Coupling Reactions provides a complete up-to-date collection of the available catalytic systems and processes. This essential reference covers a broad scope...
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| Other Authors: | , |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Hoboken, New Jersey :
Wiley,
[2013]
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| Subjects: | |
| Online Access: |
Full text (Emmanuel users only) |
Table of Contents:
- Title page; Copyright page; Foreword; Preface: Copper Catalysis from a Historical Perspective: A Legacy from the Past; The Historical and Remarkable First Discoveries by Fritz Ullmann and Irma Goldberg; Further Historical Developments: The Cyanation of Aryl Halides by Rosenmund and von Braun and the Arylation of Diketones and Malonates by Hurtley; From the Historical Discoveries to the Development of Modern Copper-Mediated Cross-Coupling Reactions; Modern Copper-Mediated Cross-Coupling Reactions and Their Impact in Organic Chemistry; Contributors; Part I: Formation of C-Heteroatom Bonds.
- 1: Modern Ullmann-Goldberg Chemistry: Arylation of N-Nucleophiles with Aryl Halides1.1 Introduction; 1.2 Arylation of Amines; 1.3 Arylation of Amides, Imides, and Carbamates; 1.4 Arylation of Conjugated N-Heterocycles; 1.5 Synthesis of Anilines by Coupling with Ammonia or Synthetic Equivalents; 1.6 Conclusion and Future Prospects; 2: Ullmann Condensation Today: Arylation of Alcohols and Thiols with Aryl Halides; 2.1 Introduction; 2.2 Formation of C-O Bonds via Copper-Catalyzed Cross-Coupling Reactions with Aryl Halides.
- 2.3 Formation of C-S Bonds via Copper-Catalyzed Cross-Coupling Reactions with Aryl Halides2.4 Conclusion; 3: Copper-Catalyzed Formation of C-P Bonds with Aryl Halides; 3.1 Introduction; 3.2 Arylation of Phosphines; 3.3 Arylation of Phosphine Oxides and Phosphites; 3.4 Conclusion; 4: Alternative and Emerging Reagents for the Arylation of Heteronucleophiles; 4.1 Introduction; 4.2 Chan-Lam-Evans Coupling: Copper(II)-Promoted Oxidative Aryl Transfer from Arylboron Derivatives; 4.3 Copper-Promoted Aryl Transfer from Metallated Aryl Derivatives (Nonboron).
- 4.4 Copper-Catalyzed Arylation Reactions Involving Masked S- and N-Nucleophiles4.5 Copper-Catalyzed Direct Heterofunctionalization of Aromatic C-H Bonds; 4.6 Conclusion and Future Prospects; 5: Beyond Ullmann-Goldberg Chemistry: Vinylation, Alkynylation, and Allenylation of Heteronucleophiles; 5.1 Introduction; 5.2 Copper-Mediated Alkenylation of Heteronucleophiles: Among the Best Routes to Heteroatom-Substituted Alkenes; 5.3 Alkynylation of Heteronucleophiles: The Emergence of General Methods for the Synthesis of Heteroatom-Substituted Alkynes.
- 5.4 Allenylation of Heteronucleophiles: New Tools for the Synthesis of Allenamides5.5 Conclusion and Future Prospects; 6: Aromatic/Vinylic Finkelstein Reaction; 6.1 Introduction; 6.2 Copper-Mediated Halogen Exchange Reactions in Aryl Halides; 6.3 Most Recent Developments and Overview; 7: Insights into the Mechanism of Modern Ullmann-Goldberg Coupling Reactions; 7.1 General View and Key Mechanistic Aspects; 7.2 Oxidation State of Copper Catalysts; 7.3 Identity of the Active Copper(I) Complex; 7.4 Activation Mode of Aryl Halides by Copper Complexes.